Expectation Might Impact Placebo Response in Parkinson’s Patients

Based on recent study carried out in Canada, patients suffering from Parkinson’s Disease show enhanced brain chemical reaction just simply because they’ve an expectation of obtaining a useful drug although they’ve been given a placebo instead.

The study was conducted on 35 individuals suffering from either mild or moderate Parkinson’s Disease. These patients had been becoming treated with the assist of a drug known as levodopa. At the begin of the study, the patients had to undergo PET scans of the brain. Then they had been given the drug and had been subjected to an additional scan.

On the 2nd day of the study, the participants had been informed separately that they had a 25, 50, 75 or 100 percent chance of obtaining the drug prior to they had a brain scan. Nevertheless, none of the participants had been given the drug. Instead they had been all given a placebo.

On checking the participants, it was discovered that those that had been informed that they had a 75 percent chance of obtaining the drug showed considerably greater amounts of dopamine, which is really a neurotransmitter. This impact was not observed in any of the other patients.

The strange component of the study is that the release of much more quantity of dopamine was only observed when the participants had been informed that they had 3 in 4 chance of receiving the drug and not when they had been informed that they had a hundred percent surety of receiving the drug.

Nevertheless, researchers claim that the result is what they expected and in line with dopaminergic activation, which occurs when an individual expects a reward but isn’t particular of obtaining it. Essentially what this indicates is that when a patient is particular that he or she is going to obtain the drug, the dopamine reward response isn’t observed.

The reason this new study is essential as clinical trials could be created taking into consideration the dopamine reward response.